研究業績

Fukushima T, Togasaki K, Hamamoto J, Emoto K, Ebisudani T, Mitsuishi A, Sugihara K, Shinozaki T, Okada M, Saito A, Takaoka H, Ito F, Shigematsu L, Ohta Y, Takahashi S, Matano M, Kurebayashi Y, Ohgino K, Sato T, Kawada I, Asakura K, Hishida T, Asamura H, Ikemura S, Terai H, Soejima K, Oda M, Fujii M, Fukunaga K, Yasuda H*, Sato T*.
An organoid library unveils subtype-specific IGF-1 dependency via a YAP-AP1 axis in human small cell lung cancer.
Nature Cancer. 2025 in press.

Igarashi R, Oda M, Okada R, Yano T, Takahashi S, Pastuhov S, Matano M, Masuda N, Togasaki K, Ohta Y, Sato S, Hishiki T, Suematsu M, Itoh M, Fujii M, Sato T*.
Generation of human adult hepatocyte organoids with metabolic functions.
Nature. 2025; 641: 1248–1257

Tamagawa H, Fujii M*, Togasaki K, Seino T, Kawasaki S, Takano A, Toshimitsu K, Takahashi S, Ohta Y, Matano M, Kawasaki K, Machida Y, Sekine S, Machinaga A, Sasai K, Kodama Y, Kakiuchi N, Ogawa S, Hirano T, Seno H, Kitago M, Kitagawa Y, Iwasaki E, Kanai T, Sato T*.
Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma.
Nature Cell Biol. 2024;26:1759-1772.

Sugimoto S, Kobayashi E*, Fujii M, Ohta Y, Arai K, Matano M, Ishikawa K, Miyamoto K, Toshimitsu K, Tkahashi S, Nanki K, Hakamata Y, Kanai T, Sato T*.
An organoid-based organ repurposing approach to treat short bowel syndrome.
Nature. 2021:99-104.

Ohta Y, Fujii M, Takahashi S, Takano A, Nanki K, Matano M, Hanyu H, Saito M, Shimokawa M, Nishikori S, Hatano Y, Ishii R, Sawada K, Machinaga A, Ikeda W, Imamura T, Sato T*
Cell-matrix interface regulates dormancy in human colon cancer stem cells.
Nature. 2022; 608:784-794.

Nanki K, Fujii M,Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R,　Yoshida K, Sasaki N, Hibi T, Ishihara S, Kanai T, Sato T*.
Somatic inflammatory gene mutations in human ulcerative colitis epithelium.
Nature. 2020;577:254-259.

Kawasaki K, Toshimitsu K, Matano M, Fujita M, Fujii M, Togasaki K, Ebisudani T, Shimokawa M, Takano A, Takahashi S, Ohta Y, Nanki K, Igarashi R, Ishimaru K, Ishida H, Sukawa Y, Sugimoto S, Saito Y, Maejima K, Sasagawa S, Lee H, Kim HG, Ha K, Hamamoto J, Fukunaga K, Maekawa A, Tanabe M, Ishihara S, Hamamoto Y, Yasuda H, Sekine S, Kudo A, Kitagawa Y, Kanai T, Nakagawa H, Sato T*.
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Cell. 2020;183 :1420-1435.

Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T*, Kanai T*
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.
Nature Microbiol. 2019:3:492-503.

Fujii M, Matano M, Toshimitsu K, Takano A, Mikami Y, Nishikori S, Sugimoto S, Sato T*.
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell Stem Cell. 2018 ;23:787-793.

Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, Matano M, Seino T, Nishikori S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y, Ishida H, Sugimoto S, Kawakubo H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T, Sato T*.
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Cell. 2018;174:856-869.

Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M, Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa Y, Kanai T, Sato T*.
Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.
Cell Stem Cell. 2018 ;22:454-467.

Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato Y, Nakamura N, Kanai T, Sato T*.
Reconstruction of the human colon epithelium in vivo.
Cell Stem Cell. 2018;22:454-467

Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T, Sato T*.
Visualization and targeting of LGR5+ human colon cancer stem cells.
Nature 2017;545:187-192.

Matano M, Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, Watanabe T, Kanai T, Sato T*
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.
Nature Medicine. 2015;21:256-62.

Sato T*, Clevers H*. Growing Self-organizing Mini-guts from a Single Intestinal Stem Cell: Mechanism and Applications.
Science. 2013; 340: 1190-4

Date S, Sato T* Mini-Gut Organoids: Reconstitution of the Stem Cell Niche.
Annu Rev Cell Dev Biol. 2015;31:269-89.

Fujii M*, Sato T*. Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases.
Nature Materials. 2021:156-169

Fujii M*, Sekine S, Sato T*. Decoding the basis of histological variation in human cancer.
Nature Rev Cancer. 2024;24:141-158.