Tamagawa H, Fujii M, Togasaki K, Seino T, Kawasaki S, Takano A, Toshimitsu K, Takahashi S, Ohta Y, Matano M, Kawasaki K, Machida Y, Sekine S, Machinaga A, Sasai K, Kodama Y, Kakiuchi N, Ogawa S, Hirano T, Seno H, Kitago M, Kitagawa Y, Iwasaki E, Kanai T, Sato T. Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma. Nat Cell Biol. 2024 Oct;26(10):1759-1772. [PMID:39232216] *プレスリリースはこちら ※博士学位論文
Endo R, Sugimoto S, Shirosaki K, Kato H, Wada M, Kanai T, Sato T. Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicine. Regen Ther. 2023 Jun 9;24:64-73. [PMID: 37868721]
Hanyu H, Sugimoto S, Sato T. Visualization of Differentiated Cells in 3D and 2D Intestinal Organoid Cultures. Methods Mol Biol. 2023;2650:141-153. [PMID: 37310630]
Ebisudani T, Hamamoto J, Togasaki K, Mitsuishi A, Sugihara K, Shinozaki T, Fukushima T, Kawasaki K, Seino T, Oda M, Hanyu H, Toshimitsu K, Emoto K, Hayashi Y, Asakura K, Johnson TA, Terai H, Ikemura S, Kawada I, Ishii M, Hishida T, Asamura H, Soejima K, Nakagawa H, Fujii M, Fukunaga K, Yasuda H, Sato T.Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma. Cell Rep. 2023 Mar 28;42(3):112212. Epub 2023 Mar 6. [PMID: 36870059] ※博士学位論文
Sugimoto S, Kobayashi E, Kanai T, Sato T. In Vivo Intestinal Research Using Organoid Transplantation. Keio J Med. 2022 Dec 25;71(4):73-81. Epub 2022 Dec 1. [PMID: 36450523]
Oda M, Hatano Y, Sato T. Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium. Curr Opin Genet Dev. 2022 Oct;76:101977. Epub 2022 Sep 1. [PMID: 36058061]
Ishikawa K, Sugimoto S, Oda M, Fujii M, Takahashi S, Ohta Y, Takano A, Ishimaru K, Matano M, Yoshida K, Hanyu H, Toshimitsu K, Sawada K, Shimokawa M, Saito M, Kawasaki K, Ishii R, Taniguchi K, Imamura T, Kanai T, Sato T. Identification of Quiescent LGR5+ Stem Cells in the Human Colon. Gastroenterology. 2022 Aug 10:S0016-5085(22)00912-X. [PMID: 35963362] *プレスリリースはこちら ※博士学位論文
Ohta Y, Fujii M, Takahashi S, Takano A, Nanki K, Matano M, Hanyu H, Saito M, Shimokawa M, Nishikori S, Hatano Y, Ishii R, Sawada K, Machinaga A, Ikeda W, Imamura T, Sato T. Cell-matrix interface regulates dormancy in human colon cancer stem cells. Nature. 2022 Jul 7. [PMID: 35798028] *プレスリリースはこちら ※博士学位論文
Toshimitsu K, Takano A, Fujii M, Togasaki K, Matano M, Takahashi S, Kanai T, Sato T. Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer. Nat Chem Biol. 2022 Mar 10. [PMID: 35273398] *プレスリリースはこちら ※博士学位論文
Wakisaka Y, Sugimoto S, Sato T. Organoid Medicine for Inflammatory Bowel Disease. Stem Cells. 2022 Mar 16;40(2):123-132. [PMID: 35258629]
Sugimoto S, Iwao Y, Shimoda M, Takabayashi K, Sato T, Kanai T; Keio IBD Collaborators. Epithelium Replacement Contributes to Field Expansion of Squamous Epithelium and Ulcerative Colitis-Associated Neoplasia. Gastroenterology. 2022 Jan;162(1):334-337.e5. doi: 10.1053/j.gastro.2021.09.051. Epub 2021 Sep 29. [PMID: 34597671]
Sugimoto S, Sato T. Organoid vs In Vivo Mouse Model: Which is Better Research Tool to Understand the Biologic Mechanisms of Intestinal Epithelium? Cell Mol Gastroenterol Hepatol. 2021 Oct 10; 2022;13(1):195-197. [PMID: 34644539]
Ebisudani T, Sugimoto S, Haga K, Mitsuishi A, Takai-Todaka R, Fujii M, Toshimitsu K, Hamamoto J, Sugihara K, Hishida T, Asamura H, Fukunaga K, Yasuda H, Katayama K, Sato T. Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening. Cell Rep. 2021 May 19;109218. [PMID: 34038715] *プレスリリースはこちら
Sugimoto S, Kobayashi E, Fujii M, Ohta Y, Arai K, Matano M, Ishikawa K, Miyamoto K, Toshimitsu K, Takahashi S, Nanki K, Hakamata Y, Kanai T, Sato T. An organoid-based organ-repurposing approach to treat short bowel syndrome. Nature. 2021 Apr;592(7852):99-104. [PMID: 33627870] *プレスリリースはこちら
Togasaki K, Sugimoto S, Ohta Y, Nanki K, Matano M, Takahashi S, Fujii M, Kanai T, Sato T. Wnt Signaling Shapes the Histological Variation in Diffuse Gastric Cancer. Gastroenterology. 2020 Nov 17;S0016-5085(20)35404-4. [PMID: 33217450] *プレスリリースはこちら
Kawasaki K, Toshimitsu K, Matano M, Fujita M, Fujii M, Togasaki K, Ebisudani T, Shimokawa M, Takano A, Takahashi S, Ohta Y, Nanki K, Igarashi R, Ishimaru K, Ishida H, Sukawa Y, Sugimoto S, Saito Y, Maejima K, Sasagawa S, Lee H, Kim HG, Ha K, Hamamoto J, Fukunaga K, Maekawa A, Tanabe M, Ishihara S, Hamamoto Y, Yasuda H, Sekine S, Kudo A, Kitagawa Y, Kanai T, Nakagawa H, Sato T. An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping. Cell. 2020 Oct 30;S0092-8674(20)31387-8. [PMID: 33159857] *プレスリリースはこちら
Sasaki N, Miyamoto K, Maslowski KM, Ohno H, Kanai T, Sato T. Development of a Scalable Co-Culture System for Gut Anaerobes and Human Colon Epithelium. Gastroenterology. 2020 Mar 18;S0016-5085(20)30363-2. [PMID: 32199883]
Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R, Yoshida K, Sasaki N, Hibi T, Ishihara S, Kanai T, Sato T. Somatic Inflammatory Gene Mutations in Human Ulcerative Colitis Epithelium. Nature. 2020 Jan;577(7789):254-259. [PMID: 31853059] *プレスリリースはこちら
Kawasaki K, Fujii M, Sugimoto S, Ishikawa K, Matano M, Ohta Y, Toshimitsu K, Takahashi S, Hosoe N, Sekine S, Kanai T, Sato T. Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma. Gastroenterology. 2020 Feb;158(3):638-651. [PMID: 31622618] ※博士学位論文
Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T, Kanai T. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis. Nat Microbiol. 2019 Mar;4(3):492-503. [PMID: 30643240] *プレスリリースはこちら
Fujii M, Clevers H, Sato T. Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids. Gastroenterology. 2019 Feb;156(3):562-576. [PMID: 30476497]
Fujii M, Matano M, Toshimitsu K, Takano A, Mikami Y, Nishikori S, Sugimoto S, Sato T. Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition. Cell Stem Cell. 2018 Dec 6;23(6):787-793. [PMID: 30526881] *プレスリリースはこちら
Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, Matano M, Seino T, Nishikori S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y, Ishida H, Sugimoto S, Kawakubo H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T, Sato T. Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis. Cell. 2018 Aug 9;174(4):856-869. [PMID: 30096312] *プレスリリースはこちら ※博士学位論文
Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato Y, Nakamura T, Kanai T, Sato T. Reconstruction of the Human Colon Epithelium In Vivo. Cell Stem Cell. 2018 Feb 1;22(2):171-176. [PMID: 29290616] *プレスリリースはこちら ※博士学位論文
Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M, Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa Y, Kanai T, Sato T. Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression. Cell Stem Cell. 2018 Mar 1;22(3):454-467. [PMID: 29337182] *プレスリリースはこちら ※博士学位論文
Shimokawa M*, Ohta Y*, Nishikori S, Matano M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T, Sato T. Visualization and targeting of LGR5+ human colon cancer stem cells. Nature. 2017 May 11;545(7653):187-192. [PMID: 28355176] *プレスリリースはこちら ※博士学位論文
Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K, Ohta Y, Toshimitsu K, Nakazato Y, Kawasaki K, Uraoka T, Watanabe T, Kanai T, Sato T. A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor requirements during Tumorigenesis. Cell Stem Cell. 2016 Jun 2;18(6):827-38. [PMID: 27212702] *プレスリリースはこちら ※博士学位論文
Fujii M, Matano M, Nanki K, Sato T. Efficient enetic engineering of human intestinal organoids using electroporation. Nat Protoc. 2015 Oct;10(10):1474-85. [PMID: 26334867]
Matano M, Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, Watanabe T, Kanai T, Sato T. Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat Med. 2015 Mar;21(3):256-62. [PMID: 25706875] *プレスリリースはこちら